DPD/DPYD Mutation Analysis

Understanding DPD/DPYD Mutation Analysis

The DPD/DPYD Mutation Analysis test is a genetic test used to identify mutations in the DPYD gene, which codes for the Dihydropyrimidine Dehydrogenase (DPD) enzyme. This enzyme plays a vital role in breaking down and removing fluoropyrimidine-based chemotherapy medicines, such as 5-Fluorouracil (5-FU) and Capecitabine, from the body.

Some people are born with reduced or absent DPD enzyme activity due to inherited DPYD gene mutations. When such individuals receive standard doses of fluoropyrimidine chemotherapy, th...

What does DPD/DPYD Mutation Analysis measure?

The DPD/DPYD Mutation Analysis test detects mutations in the DPYD gene, which provides instructions for making the enzyme Dihydropyrimidine Dehydrogenase (DPD). This enzyme is essential for breaking down certain chemotherapy medicines like 5-Fluorouracil (5-FU) and Capecitabine. The test helps identify individuals who may have DPD deficiency, a condition that can cause severe or even life-threatening side effects when treated with standard doses of these medicines. Early detection allows doctors to adjust chemother...